Thank you Dr. John Hollowed for an excellent presentation on acute promyelocytic leukemia

Teaching Points

  • APL accounts for 5-20% of AML cases
  • Increased incidence in people with prior cytotoxic therapy
  • Presents with complications of pancytopenia, weakness, fatigue, infections, increased bruising/bleeding, DIC
  • Diagnosis: bone marrow analysis and confirmation with PCR, FISH, or cytogenic analysis
  • Treatment is All-trans Retinoic Acid (ATRA)

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