Thanks to Dr. Nicole Mandich for a great presentation on Multiple Myeloma

Learning Points:

— Diagnostic Criteria for multiple myloma

• bone marrow plasma cells>10%
• serum monoclonal protein >3g
• organ dysfunction (CRAB criteria): Hypercalcemia (serum calcium >11.5 mg/dl [2.88 mmol/liter]), Renal insufficiency (serum creatinine >2 mg/dl), Anemia (hemoglobin <10 g/dl or >2 g/dl below the lower limit of the normal range) and Bone disease (lytic lesions, severe osteopenia, or pathologic fracture)

—  Workup includes:

• chem 10, CBC
• SPEP, UPEP, SPIF, UPIF
• bone marrow aspiration and biopsy
• Serum albumin, LDH, beta-2 microglobulin, CRP
• Metastatic bone survey: skeletal survey + PET, low dose whole body CT, MRI spine/pelvis

— Enjoy this great review article on Multiple Myeloma for more details