Time is tissue—and the brain is no exception. Here's the landmark article guiding our use of thombolytics within 4.5 hours of an acute stroke. Remember, the clock starts ticking from the patient's last well-known time, not from the time of…
This classic, often-cited article informs us that among patients in the ICU, intensive glucose control of 81-108 increased mortality as compared to a more liberal glucose target of <180. How have you applied the findings of this research to your…
Does hydrocortisone decrease mortality in patients with septic shock?
This is the landmark trial that compares a restrictive to a liberal red blood cell transfusion strategy. Here are some things to think about when reading this article: What are our current pRBC transfusion goals for most patients? How are…
The optimal duration of antibiotic treatment for ventilator-associated pneumonia (VAP) is not known. Shortening the course of therapy may help decrease antibiotic resistance and adverse effects of giving prolonged antibiotics. This study looks to establish that mortality and recurrent infections…
Sepsis continues to affect 1.5 million people and lead to 250,000 deaths in the U.S., according to the CDC. The CORTICUS study reviewed here (article below) is the landmark study evaluating the potential benefit of corticosteroids in septic patients. As…