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Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure

Always think about optimizing CHAMP meds in patients with heart failure:

  • ACE-inhibitor or ARB
  • Beta-blocker
  • Aspirin
  • Statin
  • Aldosterone antagonist for LVEF <35%

Here’s the evidence of use of spironolactone, a common aldosterone antagonist, in heart failure.

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