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Feb 01 2017

Disseminated Histoplasmosis

Morning Report

histo-microscopy

Thank you Dr. Brendan Cerk for an excellent presentation on neurocysticercosis presenting with new onset seizure

Teaching Points

  • Histoplasmosis is a common endemic mycosis, usually asymptomatic but occasionally results in severe illness
  • Hematogenous dissemination occurs during the acute infection before cellular immunity develops
  • Diagnosis: serum and urine antigen
  • Treatment: itraconazole for 12 months, if CNS then liposomal amphotericin B for 4-6 weeks then itrazonazole for an additional 12 months
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Jan 30 2017

Neurocysticercosis

Morning Report

Thank you Dr. Rajat Suri for an excellent presentation on neurocysticercosis presenting with new onset seizure

Teaching Points

  • Initial treatment for seizure: IV lorazepam 0.1mg/kg –> IV fosphenytoin –> sedation/intubation
  • Neurocysticercosis  is caused by Taenia Solium
  • Spreads hematogenously to the brain, liver, muscle
  • Diagnosis: presentation+imaging.  serum testing not reliable
  • Treatment: dexamethasone, albendazole, anti-epileptic
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