Aspergillus is extremely common in the environment (think black mold), but only rarely causes invasive infection particularly with severe immunosuppression:

• immunosuppressive therapy, e.g. for acute leukemia, hematopoietic stem cell and solid organ transplant
• severe, prolonged neutropenia
• high-dose, prolonged glucocorticoid use

Treatment options include the following, but notably excludes the common antifungal fluconazole:

• Voriconazole (triazole)
• Micafungin (echinocandin)
• Amphotericin

Read this article to learn more about use of the triazole compared with amphotericin.  Keep in mind the drug-specific risks and benefits of either antifungal.