Norfloxacin Prevents Bacterial Infection in Cirrhotics with Gastrointestinal Hemorrhage
EBM, Landmark Research
This is an early study showing the benefits of adjunctive antibiotic therapy when cirrhotic patients present with GI bleed.
STOP-IT: Is a Short Course of Antibiotics Adequate for Intraabdominal Infections?
EBM, Journal Club
Current antibiotic stewardship guidelines at Olive View recommend 4 days of antibiotics for intraabdominal infections once source control is achieved. Here is clinical evidence of this "short" duration of antibiotics.
Symptom-triggered versus Fixed-schedule Doses of Benzodiazepine for Alcohol Withdrawal
EBM, Landmark Research
The Ativan Protocal at Olive View is a symptom-based algorithm for treatment of alcohol withdrawal. Here's the evidence for use of the symptom-based CIWA scale to determine the dosing of lorazepam as compared to fixed dosing of benzodiazepine. Read the…
Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis (RAVE)
EBM, Landmark Research
Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (ADRENAL)
EBM, Journal Club
Does hydrocortisone decrease mortality in patients with septic shock?
Comparison of carvedilol and metoprolol on clinical outcomes in patients with CHF (COMET)
EBM, Landmark Research
Clinical Question: What is the effect of carvedilol vs metoprolol tartrate on mortality and morbidity in patients with heart failure with reduced ejection fraction (HFrEF) and NYHA class II-IV symptoms? Take Away: In patients with HFrEF, carvedilol reduces all-cause mortality…
Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy
EBM, Landmark Research
Clinical Question: As compared to placebo, does the angiotensin-II-receptor agonist (ARB) losartan delay progression to ESRD and improve mortality in patients with type 2 diabetes and nephropathy?
Defining Community-Acquired Pneumonia Severity on Presentation to Hospital
EBM, Landmark Research
CURB-65: the easy-to-use clinical prediction rule helps us triage patients with pneumonia to inpatient or outpatient care. What is this actually based upon? This is the original study used to develop the CURB-65. Here are some things to think about…
Multicenter Randomized Controlled Clinical Trial of Transfusion Requirements in Critical Care (TRICC)
EBM, Landmark Research
This is the landmark trial that compares a restrictive to a liberal red blood cell transfusion strategy. Here are some things to think about when reading this article: What are our current pRBC transfusion goals for most patients? How are…
A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation (AFFIRM)
EBM, Landmark Research
Rate control over rhythm control - that's the fundamental principle in treatment of atrial fibrillation, and here's the why we do this. Read the landmark article below and as a group, review the presentation here on TrialGuru.org.