Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest
EBM, Landmark Research
Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
EBM, Landmark Research
Always think about optimizing CHAMP meds in patients with heart failure: ACE-inhibitor or ARB Beta-blocker Aspirin Statin Aldosterone antagonist for LVEF <35% Here's the evidence of use of spironolactone, a common aldosterone antagonist, in heart failure.
Dexamethasone in Adults with Bacterial Meningitis
EBM, Landmark Research
The mainstay of treatment for bacterial meningitis are: High-dose IV antibiotics: Ceftriaxone, Vancomycin, +/- Ampicillin Steroids Patient isolation Here's the evidence for using steroids in bacterial meningitis.
Intensive versus Conventional Glucose Control in Critically Ill Patients (NICE-SUGAR)
EBM, Landmark Research
This classic, often-cited article informs us that among patients in the ICU, intensive glucose control of 81-108 increased mortality as compared to a more liberal glucose target of <180. How have you applied the findings of this research to your…
Early Palliative Care for Patients with Metastatic Lung Cancer
EBM, Landmark Research
This article helps us to answer: What is the effect of early introduction of palliative care to ambulatory patients soon after diagnosis of metastatic non-small-cell lung cancer (NSCLC) on quality of life outcomes and end-of-life care?
Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia
EBM, Landmark Research
Norfloxacin Prevents Bacterial Infection in Cirrhotics with Gastrointestinal Hemorrhage
EBM, Landmark Research
This is an early study showing the benefits of adjunctive antibiotic therapy when cirrhotic patients present with GI bleed.
Symptom-triggered versus Fixed-schedule Doses of Benzodiazepine for Alcohol Withdrawal
EBM, Landmark Research
The Ativan Protocal at Olive View is a symptom-based algorithm for treatment of alcohol withdrawal. Here's the evidence for use of the symptom-based CIWA scale to determine the dosing of lorazepam as compared to fixed dosing of benzodiazepine. Read the…
Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis (RAVE)
EBM, Landmark Research
Comparison of carvedilol and metoprolol on clinical outcomes in patients with CHF (COMET)
EBM, Landmark Research
Clinical Question: What is the effect of carvedilol vs metoprolol tartrate on mortality and morbidity in patients with heart failure with reduced ejection fraction (HFrEF) and NYHA class II-IV symptoms? Take Away: In patients with HFrEF, carvedilol reduces all-cause mortality…