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Evidence-Based Medicine

Landmark Research Series

Welcome to the core landmark research series.  The landmark studies have been listed below by topic. Click on the title and review the presentations summarizing the research with our team.

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General Internal Medicine

DASH

Adhering to the DASH diet demonstrated a reduction in blood pressure
Review Study

CURB 65

A simple, validated tool to assist in predicting risk and triaging patients with community acquired pneumonia
Review Study

JUPITER

Rosuvastatin reduces first incidence of major cardiac events
Review Study
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Cardiology

RALES

Spironolactone improves mortality and morbidity in patients with HFrEF
Review Study

JUPITER

Rosuvastatin reduces first incidence of major cardiac events
Review Study
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Hematology

MSH

Use of hydroxyurea decreases number of yearly pain crises in sickle-cell disease
Review Study

ITP

Oral dexamethasone is an effective initial treatment in immune thrombocytopenic purpura
Review Study
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Hepatology

MELD

A strongly validated prognostic indicator for mortality in cirrhosis and prioritization of liver transplantation
Review Study
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Infectious Disease

C. diff Treatment

Vancomycin vs Metronidazole for initial treatment of C. diff colitis
Review Study

CURB 65

A simple, validated tool to assist in predicting risk and triaging patients with community acquired pneumonia
Review Study
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Neurology

ECASS III

Alteplase may be safely administered in treatment of acute ischemic stroke in the extended period of 3 to 4.5 hours after symptom onset
Review Study
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Oncology

Palliation in NSCLC

Early palliative care in patients with NSCLC improves outcomes and quality of life
Review Study
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Pulmonary & Critical Care

TRICC

A more conservative transfusion goal improves outcomes in critically ill patients
Review Study

HACA

Targeted cooling shows improved neurologic outcomes after obtaining ROSC following cardiac arrest from Vfib
Review Study
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