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Voriconazole Versus Amphotericin B for Primary Therapy of Invasive Aspergillosis

Aspergillus is extremely common in the environment (think black mold), but only rarely causes invasive infection particularly with severe immunosuppression:

  • immunosuppressive therapy, e.g. for acute leukemia, hematopoietic stem cell and solid organ transplant
  • severe, prolonged neutropenia
  • high-dose, prolonged glucocorticoid use

Treatment options include the following, but notably excludes the common antifungal fluconazole:

  • Voriconazole (triazole)
  • Micafungin (echinocandin)
  • Amphotericin

Read this article to learn more about use of the triazole compared with amphotericin.  Keep in mind the drug-specific risks and benefits of either antifungal.

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