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Landmark Research Series

Comparison of carvedilol and metoprolol on clinical outcomes in patients with CHF (COMET)

Clinical Question: What is the effect of carvedilol vs metoprolol tartrate on mortality and morbidity in patients with heart failure with reduced ejection fraction (HFrEF) and NYHA class II-IV symptoms?

Take Away: In patients with HFrEF, carvedilol reduces all-cause mortality compared to metoprolol tartrate.

 

 

Intensive versus Conventional Glucose Control in Critically Ill Patients (NICE-SUGAR)

This classic, often-cited article informs us that among patients in the ICU, intensive glucose control of 81-108 increased mortality as compared to a more liberal glucose target of <180.  How have you applied the findings of this research to your practice?

Rosuvastatin to Prevent Vascular Events (JUPITER)

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